Global Journal of Molecular Evolution and Genomic received 67 citations as per Google Scholar report
Tarek M Heikal
Pesticides have contributed for many public health hazards in man including infertility. So, the present study aims to assess the protective role of Cedrelopsis grevei leave extract against the incidence of reproductive toxicity resulting from diazinon (DIA) exposure in mature male Wistar rats. Group I served as control. Groups II rats were received 150 mg/kg extracts. Groups III rats were given DIA at a dose of 12.50 mg a.i. kg-1 b.wt., 1/100 LD50. Groups IV rats were simultaneously given the same doses of extract and DIA as in groups II and III, respectively. All the applications were given a single daily dose via oral gavage for 70 days to complete the spermatogenic cycle. The results revealed that exposure to DIA significantly decreased the fertility index, weights of sexual organs (testes, seminal vesicles, epidermis and prostate gland), sperm characteristics as well as serum testosterone level, while increased sperm abnormality. In addition, the testicular tissue level of reduced glutathione and the activities of SOD, CAT, GPx and GST enzymes were significantly decreased while increased the level of testicular tissue LPO compared with the control group. The testicular histopathological sores were described by moderate to extreme degenerative changes of seminiferous tubules and inadequate capture of spermatogenesis. Co-administration of the extract to treated-animals alleviates the reproductive toxicity and testicular oxidative damage.
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