New features of the pathogenesis of a disease of cerebral small vessels

Abstract

Yakubova M.M., Rakhimova Sh.E.,* Said-Akhmedova S.K

The etiopathogenesis of Binswanger's disease (cerebral vascular disease) is still the least studied cause of the disease. It is believed that endothelial, capillary and venular dysfunction, pathology of pericyte function, and increased BBB permeability lead to this condition. Moreover, essential arterial hypertension is not a cause, but a secondary compensatory-adaptive process in relation to cerebral microcirculatory disorders. As a result, lacunar infarction, microbleeding, leukoaraiosis and cerebral atrophy occur in the brain. Due to the lack of in-depth studies of etiopathogenesis - the Binswanger disease clinic, there are currently no means and solutions for effective treatment. Thus, an acute shortage of research and the need to continue scientific work in this direction are revealed.