Global Journal of Medicine and Medical Sciences received 470 citations as per Google Scholar report
Isana Carla Leal Souza1, Marismar Fernandes do Nascimento1, Raquel Gonçalves deSouza Neta2, José Cleveilton Dos Santos3, Luiz Pereira Costa4, Juliana Cordeiro Cardoso5and Ricardo Luiz Cavalcanti de Albuquerque-Júnior6*
The study evaluated the physical properties and healing potential of chemically modified collagenbased membranes containing hydroalcoholic extract of Brazilian red propolis (HERP) in rodents. The collagen chemical modification was carried out through Maillard’s reaction using maltodextrin as reticulant agent, and HERP was incorporated at 0.5%. The HERP-incorporated collagen-based membranes were evaluated regarding the mechanical properties, water vapor permeability and swelling rates. For the wound healing assay, surgical wounds were performed on the back of 100 rats, assigned into five groups (n = 20), whose wounds were dressed as follows: (C) – original membranes; CM – modified membranes; CP – HERP-incorporated original membranes; CMP – HERP-incorporated modified membranes; CTR – undressed wounds (control). Five animals of each group were euthanized at 3, 7, 14 and 21 days and the wounded areas were macroscopic and microscopically analyzed. The CMP-membranes showed lower thickness (p < 0.05), permeability (p < 0.001) and swelling (p < 0.05) than the C-membranes. The CMP-membranes promoted increased wound contraction rates at 3 (p < 0.01), 14 (p < 0.001) and 21 days (p < 0.01) compared to CTR, and provided earlier granulation tissue and cutaneous appendages formation, as well as better organization of the collagen deposition. In conclusion, the CMP-membranes presented advantageous properties to be used as wound dressing and improved wound healing in rodent model.
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