Global Journal of Medicinal Plants Research received 497 citations as per Google Scholar report
Aditi Bondugula, Abbie Nicholson
Hyaluronic acid plays a crucial role in the skin by increasing hydration and stimulating collagen growth (Papakonstantinou, Roth, & Karakiulakis, 2012). It has a key position in wound healing and tissue repair processes such as healing and the stimulation of growth factors, and cellular components (Gonzalez, Costa, Andrade, & Medrado, 2016). Planaria Schmidtea Mediterranea are flatworms able to regenerate parts of their body if injured within a span of five days. These flatworms contain adult totipotent stem cells called neoblasts allowing them to do so (Wagner, Wang, & Reddien, 2011). Ultraviolet radiation (UV radiation), however, damages the planarian’s abilities to regenerate tissue (Franjevic, Kalafati?, & Kovačevi?, 2006). In the present work, the effect of hyaluronic acid on two groups of ten planarians was investigated. Experimental populations of the Planarian Schmidtea Mediterranea were placed and physiological changes were monitored daily with a microscope in laboratory conditions at room temperature. Both groups of the planaria received ten seconds of UV radiation at the beginning of the experiment. Hyaluronic acid was only given to only one out of the two groups of planaria for 10 days. Data indicates that the ten deciliters of added hyaluronic acid predominantly slowed down the rate of tissue regeneration in planarians and reduced tissue regeneration rate compared to the other group of planarians. These results illustrate how hyaluronic acid had the opposite influence on planarian tissue regeneration and how it significantly diminished tissue growth.
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