Bacterial wound infections in diabetic patients and their therapeutic implications

Abstract

Ihsan Edan Abdulkareem Alsaimary

In order to identify the bacterial pathogens associated with diabetic wounds and testing the antibiotic susceptibility of main antibiotics against predominant anaerobic bacterial types in comparison with some plant extracts, a total of 27 diabetic patients in each types; Insulin dependent (IDDM) and non-insulin dependent NIDDM and 30 non-diabetic patients with wound infection were introduced in the present study that was conducted between October - December 2007. It has been found that wounds are highly infected by aerobic and anaerobic bacterial types; Propionibacterium granulosum - as anaerobic bacteria- was a predominant pathogen in diabetic wound infections, in comparison with Pseudomonas aeruginosa which is predominant in non-diabetic wounds. Amoxycillin/ calvulanic acid was the best effective antibiotic which gave 20 mm inhibition zone in comparison with other standard antibiotics, and aqueous extracts of Myrtus communis and Nerium oleander gave II and 10 mm inhibition zone, respectively.