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Farah Bokharaei-Salim
Farzin sadeghi
Mostafa Salehi-Vaziri
Seyed Hamidreza Monavari
Hossein Keyvani
Hamidreza mollaie
Roghaeh mollaie
Mehdi fazlalipour
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Farah Bokharaei-Salim
Farzin sadeghi
Mostafa Salehi-Vaziri
Seyed Hamidreza Monavari
Hossein Keyvani
Hamidreza mollaie
Roghaeh mollaie
Mehdi fazlalipour
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Global Journal of Virology and Immunology

Full Length Research paper 

Detection of human T-cell lymphotropic virus Type-1 among patients with malignant hematological diseases in Capital of Iran, Tehran

Seyed Hamidreza Monavari, Hossein Keyvani, Hamidreza mollaie, Mehdi fazlalipour, Farzin sadeghi, Mostafa Salehi-Vaziri, Roghaeh mollaie and Farah Bokharaei-Salim

1Department of Virology and Antimicrobial Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran.

2Department of Medical Virology, Tehran University of Medical Sciences, Tehran, Iran.

3Department of Medical Technology, Hazrat rasool Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Corresponding authors. E-mail: hrmonavari@yahoo.com. Tel: +98(021)88602205 

Accepted 13 October, 2013 

Human T-cell lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus linked causally to adult T-cell leukemia or lymphoma (ATL), and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The aim of this study was to detect HTLV-1 infection in patients with malignant hematological diseases and also determining the prevalence of HTLV-1 in these patient groups. Sixty patients with malignant hematological diseases were included in the study and tested by enzyme-linked immunosorbent assay (ELISA) for anti-HTLV-1, and Real time-PCR for the sequences from HTLV-1 tax gene. The mean age of patients was 33.9 ± 18.3 years. 18 of the subjects were found HTLV-1 seropositive using ELISA and the viral prevalence by Real time-PCR was 12%. HTLV-1 was found in 25% of patients with acute myelogenous leukemia (AML), 58.3% of patients with chronic myelogenous leukemia (CML), 16.7% of patients with acute lymphoblastic leukemia (ALL), and no detected in patients with lymphoma. The present study revealed that HTLV-1 is prevalent in patients with malignant hematological diseases and in our study. The major HTLV-1 associated syndromes were chronic myelogenous leukemia and acute lymphoblastic leukemia. 

Key words: Human T-cell lymphotropic virus type-1, malignant hematological diseases, prevalence, Iran.